Statistical analysis of the matrix data may be restricted because of the limited data points that mixed review evidence could provide but further analysis could explore, in a review with more methodologically robust trials, the value of using the algorithmic logic of QCA to explore variation in trial findings.
However, when only methodologically robust trials were included in the analysis a smaller effect in favour of exercise was observed.
Further research, in the form of methodologically robust randomized trials, are needed to evaluate this strategy in different maternity care systems and countries.
In the recent Cochrane systematic review and synthesis of 39 randomised controlled trials of speech and language therapy for people with aphasia, it became evident that there was room for more methodologically robust trial designs (Brady et al., 2012).
A systematic review of research on EoL care in sub-Saharan Africa uncovered 'a wealth of clinical and academic experience but a dearth of methodologically robust evidence' [ 8].
Notwithstanding the difficulties underlying the execution of this type of complex clinical trials, larger and methodologically more robust trials are very much needed to confirm the findings of the present review, and to further identify characteristics of successful programs.
Finally, based on these discussions, description of a methodologically robust, definitive clinical trial will be proposed.
Therefore, we based our feasibility assessment upon methodologically robust exercise oncology trials.
Nutritional and dietary supplementation in haemodialysis patients is an area which requires larger, more methodologically robust randomised controlled trials to determine if risk of cardiovascular outcomes can be improved.
But I remain cautious and talk about a lack of robust trials and meta-analysis.
The Malmö randomised trial, which is usually considered as methodologically robust, showed reductions in mortality eight years after the start of screening.
