13 However, the figure was greater than the findings from a meta-analysis of existing trials available at the time we initiated CADET (0.25; 0.18 to 0.32).
With this in mind we performed a meta-analysis of existing trials and treatment modalities across most common cancer types over the seven years between 2000 and 2006 inclusive.
Apart from embarking on a set of concerted new trials in this area, which may take years to complete, a potentially quicker way to salvage the situation with existing data may be joint action among sponsors and trialists of existing trials to aggregate their raw data to inform an IPD meta-analysis [ 42, 43].
To evaluate the impact on survival of V1 receptor agonists in hypovolemic refractory shock, we conducted a systematic review and meta-analysis of data pooled from existing trials comparing AVP or terlipressin and conventional shock management in mammals.
Further analysis of existing HT trials in regard to social effects would be welcome.
Given these findings and the lack of clinical trials designed to identify factors associated with the benefit of maintenance therapy, we conducted a post hoc analysis of existing clinical trial data [ 19].
In comparison to existing trials of exercise for knee OA, the strengths of the BEEP trial are its size, long-term follow-up, and inclusion of a cost-effectiveness analysis and longitudinal qualitative interviews with participants.
Finally, a meta-analysis of randomised trials of corticosteroids in head injury shows that existing trials are too small to demonstrate or to refute the possibility of a moderate but clinically important benefit [ 10].
In comparison to existing trials of injection and exercise interventions for SIS, the strengths of the SUPPORT trial are its size, long-term follow-up and inclusion of an individualised, supervised and progressed exercise programme which builds upon existing guidelines [ 4] to optimise treatment outcome [ 12- 15] and inclusion of a cost-effectiveness analysis.
The aim of this analysis was to analyse existing trials, even small and nonrandomised, and identify superior regimens.
In summary, while adverse cardiometabolic effects of IP-TFA are well established, data from the present meta-regression analysis of existing randomised controlled trials indicate that R-TFA intake levels do not substantially influence the changes in the ratios of TC:HDL-C and LDL-C HDL-C in heaLDL-C HDL-C.
