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Rather we see both as highly interrelated and consequently an analysis of escalation cannot separate the two.
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If the information on onset date and cycle was missing or incomplete, these patients were excluded from the analysis of grade escalation.
This finding is also supported by the analysis of grade escalation of NSAEs, which shows the lower frequencies in Asian studies than in Western studies in many cases (Table 3).
We designed a prospective multicentre observational study – Analysis of Antibiotic De-escalation for Nosocomial Pneumonia (ADANN) – to assess the clinical, microbiological, and pharmacoeconomic features of a carbapenem-based de-escalating strategy in intensive care unit (ICU) patients with NP.
ADANN = Analysis of Antibiotic De-escalation for Nosocomial Pneumonia; BAL = bronchoalveolar lavage; ICU = intensive care unit; MITT = modified intention-to-treat; MRSA = methicillin-resistant Staphylococcus aureus; NFGNB = nonfermenting Gram-negative bacilli; NP = nosocomial pneumonia; PE = patient-evaluable; TA = Tracheal aspirate; VAP = ventilator-associated pneumonia.
The definition of de-escalation strategy allowed us to create two groups for subsequent analysis of associated factors: 'de-escalation' group (D) and 'no de-escalation' group (ND).
To address this, Kao et al. performed a dose-escalation analysis of sunitinib both before and during RTx.
Improving alarm safety requires a systematic review of a hospital's alarm-based technologies and analysis of alarm management policies like alarm escalation strategies and staffing patterns.
Despite limited exposure (median 36 weeks), this analysis demonstrates that escalation of deferasirox to doses of >30 mg/kg per d effectively decreased serum ferritin compared with levels prior to dose escalation in patients whose serum ferritin levels were not adequately controlled before escalation.
The concept of escalation, when treated this way, can help us further the analysis of clinical and institutional acts and competence.
We are currently conducting such an analysis of VA-wide facility-level de-escalation rates in HCAP.
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