A systematic postponement analysis of end points other than all-cause mortality might thus be warranted.
Regression analysis of end points in active treatment and sham arms estimated an R of 0.78 for primary and 0.84 for secondary end points.
The principal analysis of end points will be by intention-to-treat, meaning that all randomised patients are included in their initially assigned study arm, regardless of adherence to study protocol.
We have now elaborated on our findings, such as the equidistant phloem pole patterning or the masking of growth dynamics by the sole analysis of end points, and we have added a paragraph to the Discussion that highlights the main findings with regards to divergent secondary growth dynamics between Col-0 and Ler: "Differential secondary growth dynamics in Col-0 versus Ler.
Although microarray data based on analysis of end-point PCR amplicons is not quantitative, results showed a significant signal reduction when targeting killed cells and consistently agreed with qPCR results.
Requests included a number of issues such as additional subgroup analysis, use of end points and outcomes and, most frequently, queries around the use of indirect and mixed treatment comparisons.
Shift analysis is considered better than dichotomization of end point measures, although there are differences of opinion (16, 17, 20– 20).
Events used for the analysis of the end point of disease-free survival included local, regional, and contralateral breast cancer or distant breast cancer recurrence.
A recent analysis of the end point of hospitalization for heart failure in SAVOR-TIMI 53 showed that saxagliptin therapy was associated with an increased risk of this event: more patients treated with saxagliptin (289, 3.5%) were hospitalized for heart failure compared with those allocated to placebo (228, 2.8%; HR, 1.27; 95% CI, 1.07 1.51; P = .007) [ 15].
Because of the limitations of the available survey and emerging interests in a broader range of health end points, the analysis included a number of end points without known environmental causes.
