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Coupled with an analysis of clock mutant (Clk) flies, a cell line designed to identify direct targets of the CLOCK (CLK) transcription factor and differential display, we uncovered several striking features of circadian gene networks.
Liu, H. et al. Analysis of clock gene homologs using unifoliolates as target organs in soybean (Glycine max).
Bayesian analysis of clock models using BEAST shows that relaxed molecular clock models are the likeliest for all genotypes (see Supplementary Data) and these were used for the construction of Bayesian skylines on sub-genotypes B5 and C4.
The analysis of clock gene expression in the SCN revealed that the dysfunction in this variant was possibly due to desynchronizing mechanisms among the SCN neurons.
Our aim was to predict regulatory mechanisms of the mammalian circadian clockwork by a large scale promoter analysis of clock controlled genes (CCGs).
The combination of both improved the classification considerably as compared to the exclusive analysis of clock time.
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Our methodology allows us to evolve networks in silico using various selective pressures, which we apply to the analysis of clocks evolved to be either autonomous or phase locked.
Another comparative analysis of clocks from eukaryotes established a smaller degree of conservation among protein components constituting the TTFLs compared to that of kinases and phosphatases participating in circadian oscillators, thereby providing support for phosphorylation-based signaling as a central element in the ancestral clock.
Furthermore, the use of bioluminescent clock reporters has been extensively employed for noninvasive analysis of the clock in a broad range of model species.
Recent structural studies of KaiA and KaiB, two bacterial biological clock proteins, mark the beginning of a new phase in the analysis of circadian clock mechanisms.
With regard to the Raman analysis of the clock east face/VN2, the same compounds found in the west face/VN1 (see above) were found.
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