We conducted a meta-analysis of available trials comparing treatment of humeral shaft fractures.
Given these uncertainties, we conducted a meta-analysis of available trials to identify what role, if any, statin therapy might have in the development of type 2 diabetes.
This possibility complicates the analysis of results of available trials on the long-term effects of improvement of metabolic control.
A large meta-analysis in 2005 of available trials (8) showed that in diabetes all major antihypertensive drug classes protect against cardiovascular complications, probably because of the protective effect of blood pressure lowering per se.
26 33 34 Network meta-analysis allows a unified analysis of the entire set of available trials by combining all direct within trial comparisons with indirect between trial comparisons of interventions constructed from trials that have one intervention in common, while fully respecting randomisation.
In the interpretation of the results of this meta-analysis, the limited number of available trials, the methodological quality of the included trials and the heterogeneity of the included trials should be noted.
This meta-analysis provides a comprehensive summary of available trial information for clinicians and guideline developers.
In spite of this, a meta-analysis of all available trials that include users of low-dose ASA combined with NSAIDs (traditional or selective) showed a lower GI complication risk in the group of selective COX-2 NSAID plus low-dose ASA users compared with ns-NSAID plus low-dose ASA users (RR, 0.72; 95% CI, 0.62 to 0.95) [ 19].
A meta-analysis of the available trials from the Cochrane collaboration concluded that COX-2 selective inhibitor (celecoxib) was associated with less symptomatic ulcers, endoscopically detected ulcers and discontinuations for GI adverse events compared with ns-NSAIDs (naproxen, diclofenac, ibuprofen and loxoprofen) [ 5].
A pre-2001 analysis of available published clinical trials of the OA/RA drug rofecoxib would have highlighted the limited participation of arthritis patients with cardiovascular morbidity; and an examination of the medications prescribed to real-world Australian OA/RA patients aged over 65 years would have shown that some 68% of these arthritis patients carried a cardiovascular risk.
Hence, we conducted a meta-analysis of available clinical trials to evaluate the efficacy of oral chlorhexidine application on the incidence of NP in patients who required mechanical ventilation.
