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This approach is suitable for an analysis of asymmetries but neglects the harmony of the face [ 4].
While the analysis of asymmetries of evolution rates may be advantageous, the choice of a good measure of asymmetry is not obvious, given that different pairs of paralogs vary greatly in their evolutionary rates and/or degree of divergence.
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Historically, a 2D analysis of asymmetry with facial photographs has complemented a clinical examination using linear and planar differences between each side of the face which are prone to measurement error [19].
We repeated FET based analysis of asymmetry on the reduced sequences, which is a concatenation of all annotated domains.
Third, a domain-centric analysis of asymmetry uniquely enables biological interpretation via functional investigation of the asymmetrically evolving domains.
We repeated the FET based analysis of asymmetry independently on each annotated domain of each gene paralog.
The authors present an analysis of asymmetry in sequence evolution, expression level, expression specificity and segregating non-synonymous polymorphisms in paralogs present in 12 Drosophila genomes by using singleton orthologs as controls.
Two pioneering studies by Smith and Menzel and Guerrieri et al. in honeybees allowed for extensive analysis of asymmetry in generalization with regards to molecular structure, as both studies used different volatile floral odours varying in either chain length or functional group.
There are several important caveats that make the analysis of rates' asymmetries in paralogs difficult and prone to false negatives.
There are several advantages for this paper, which includes the breadth of data obtained for the analysis, a good selection of genes for the paralog-orthologue comparison and what I thought was a good statistical analysis of rate asymmetries.
The analysis of manual asymmetries in human and nonhuman primates has provided some answers to the question of whether or not there is a common substrate for language and handedness.
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