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This was true when we performed the analysis in the prospective cohort based on the number of pyuria episodes in the first year of follow up.
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The strength of the analysis lies in the prospective nature of our studies.
The analysis consisted in the prospective collection of specific indicators, which must be gathered for all eligible patients (following the inclusion criteria established by the multidisciplinary team) consecutively admitted to hospital in a given period (the same dynamic target population).
A cost-effectiveness analysis was performed in the prospective population comparing the cost of MP analysis with the amount saved by CHT reduction.
However, one patient in our retrospective analysis and 2 patients in the prospective analysis were infected with S. suis serotype 14.
Importantly, this heterogeneity was not present in the meta-analysis of individual participant data studies with harmonised exposure and outcome measures (I=18%, P=0.21 in the cross-sectional analysis; 0%, P=0.99 in the prospective analysis).
Only two of the SNPs that were found to be significantly associated with T2DM in the case-control analysis were validated in the prospective study.
In the present study, we confirmed that SNPs rs2237892 in KCNQ1 was in relation to T2DM and IGR with the odds ratio of 1.35 and 1.17 respectively in the case-control analysis, but not in the prospective study.
After 1 1 matching, 208 patients were finally included in the analysis: 104 patients in the prospective routine nurse's protocol-directed weaning procedure (cases) and 104 patients in the standard physician-directed weaning procedure (controls).
These have been identified to have prognostic value in a recent analysis of the PROspective PioglitAzone Clinical Trial In MacroVascular Events (PROactive) trial, where electrocardiographic signs such as heart rate, QTc-interval and bundle branch blocks were predictive for adverse outcome [ 65].
Three logistic regression models with different adjustments were used to investigate effect of risk scores on T2DM and IGR in the case-control analysis and on incident diabetes in the prospective analysis, respectively.
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