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Also, it has combined them at the level of individual data, rather than the more usual meta-analysis method of running the analysis in each study individually, and then pooling the results.
The same laboratory performed PFOA analysis in each study.
The findings of this meta-ethnographic study are limited by the nature and depth of data collection and analysis in each study.
An estimate of relative risk (rate ratio, risk ratio or OR) with any measures taken to address confounding was extracted from each eligible independent analysis in each study.
We assessed assumptions underpinning analysis in each study and substituted conservative results where assumptions may have been generous (e.g. we assumed smoking cessation participants lost to follow up had resumed smoking).
The mean baseline values were calculated by combining mean values from the intervention and control groups, weighted by the number of participants in the final analysis in each study group.
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To comprehend the potential gains of such two-stage meta analysis over individual analysis in each single study cohort, we constructed study-wise gene expression signatures using the same method.
The stability of the summary risk estimate was evaluated using a sensitivity analysis in which each study was individually removed and the odds ratio was recalculated.
These differences could be due to technical differences in the cDNA array platforms, to the methods of analysis used in each study, or (most probably) to patient inclusion criteria.
As the aim was to summarise the geospatial analysis methods reported in each study, some items of the PRISMA statement were not applicable (e.g. there was no formal assessment of risk of bias), nor was a quality assessment of the reviewed studies undertaken given the focus was on the adopted analysis methods only.
The relatively weak overlap between C. briggsae and C. elegans GLD-1 targets could be due to the different microarray analysis methods employed in each study.
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