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When stratified by type, 12.27% (8.56%, 15.97%) for influenza A and 5.50% (3.49%, 7.51%) for influenza B. Trials that reported outcomes specifically on adults and children were included in this analysis and trials that reported on mixed populations were excluded.
We extracted the number of patients initially randomised and the number of patients analysed per group at each time point to distinguish between trials that had included all randomised patients in the analysis (intention to treat analysis) and trials that had not.
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The general process of model-based trial design and analysis is described and several examples demonstrate the value in historical data, simulation-guided design, model-based analysis and trial adaptation informed by interim analysis.
Effects of perioperative statin use on cardiovascular complications in patients submitted to non-cardiac surgery: protocol for a systematic review, meta-analysis, and trial sequential analysis.
Cochrane systematic review methodology with meta-analysis and trial sequential analysis of randomized trials comparing the effect of psychodynamic therapies versus 'treatment as usual' for major depressive disorder.
The results of our systematic review with meta-analysis and trial sequential analysis show that randomized trials with low risk of systematic errors (bias) and low risk of random errors (play of chance) are needed.
Design Systematic review of randomised controlled trials with meta-analysis and trial sequential analysis (TSA).
KT is a biostatistician working with meta-analysis and trial sequential analysis at the Copenhagen Trial Unit.
JB is an intern working in paediatrics with meta-analysis and trial sequential analysis.
Our five-point assessment is in agreement with results from systematic reviews with meta-analysis and trial sequential analysis [ 91].
This meta-analysis and trial sequential analysis will be reported according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guideline.
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