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In addition, they present experimental results involving the use of ConTra in analysing datasets of different sizes.
We explore genome-scale analyses, analysing datasets with hundreds to thousands of genes, which are too large for BUCKy-pop and *BEAST to analyse.
The sample size was limited in this study, which is a pointer for potential future research, which would benefit from analysing datasets with a larger sample size.
We tested BiForce and BOOST in analysing datasets with 1000 samples and different numbers of SNPs on a single workstation (2.8 GHz Intel Core iMAC with 4 GB RAM and four CPU cores each with two threads) to give a fair comparison.
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In this section, the procedures for generating and analysing dataset(s) used in the paper are explained in detail.
Each normalized dataset has a raw source dataset, but the mapper hierarchy is flexible, so that analysed datasets built from other analysed datasets (e.g. where the differential of control and drug screens is calculated) can also be included.
For all analyses, datasets containing gene identifiers and corresponding delta methylation values were uploaded into IPA.
Future work will entail using the method to analyse datasets for more heterogeneous food matrices.
GEE models have routinely been used to analyse datasets containing repeated measures, including longitudinal IDU cohorts [ 20, 21].
The single analysis results show all up- and downregulations of the genes of interest in all individually analysed datasets.
This advance enables us to analyse datasets, which could not otherwise be practically analysed, such as the 15 000 individual WTCCC cohort (The Wellcome Trust Case Control, 2007).
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