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This not only drastically reduces the number of animals required for a study but also offers the appealing possibility of longitudinal analyses within the same animal.
In contrast to the IPD and AOM data summarized in Table 1, there does not appear to be evidence of a consistent 7vCRM effect on 19A colonization itself (Table 2), even among different analyses within the same vaccine study population [ 21- 23].
Fit to the Rasch model allows for a transformation of scores, where the raw scores consisting of ordinal data can be converted into a logit interval scale and transformed into a metric estimate score for use in parametric statistical analyses within the same range as the original MFI-20 scores [ 25].
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Blood samples were collected and analysed within the same day.
For all protein analyses, CSF and serum samples were analysed within the same analytical series.
Samples of cases and matched controls were analysed within the same analytical batch.
Case and control specimens were analysed within the same batch in random order and laboratory personnel were blinded to the case control status of each individual.
Cases and matched controls were analysed within the same analytical batch by laboratory technicians blinded to case control status and identity of quality control samples.
Owing to the relatively large difference in response rates among the three groups, we calculated the responses for each group and subgroup, and we limited the statistical analyses to within the same group.
The upper painting has equal contribution in both spectra as both spots analysed lie within the same homogeneous area of Christ's hand (Fig. 1a).
Therefore, classification as strong evidence requires that the data are validated by multiple biological and technical replicates, which may be analysed either within the same study or even better, independent studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com