Results from the single-subject analyses were integrated at the group level in a model treating participants as random effects (Holmes & Friston, 1998).
In this study, Data mining and dynamic network analyses were integrated to examine the gene regulatory network in the inflammatory response system.
The in vitro and in vivo gene expression matrices were analysed jointly by compound and the resulting disconnected genes from the separate analyses were integrated using the Bimax biclustering algorithm [ 27] in order to identify subsets of disconnected genes that are common to several compounds.
Sedimentological observations, planktonic microfossil data, terrigenous index proxy data, benthic morphogroup analyses, pressure analyses and geochemical fingerprinting were integrated in order to assess the nature of mudstones in the Cardamom Field in the Auger salt withdrawal minibasin (Gulf of Mexico).
H-DD, SS, AR, RS, TN, CL, CEA and FM participated in the design of the study as well as in the acquisition of data throughout the study and were integrated in the analyses and interpretation of the results.
In addition to these two main variables, other aspects that were also intended to operationalise the concept of 'supportive care' or that were thought to influence the concept of 'supportive care' directly or indirectly as framing factors were integrated in the analyses.
Additionally, antimicrobial administration, ligation material used during surgery, presence of peritonitis at surgery, administered drugs (anesthetic agents, analgesics, i.v. fluid therapy), duration of postoperative hospitalization and uterine diameter (as determined by ultrasonography or macroscopically during surgery) were integrated in the analyses.
The authors demonstrated the power of their method to identify the MoA of novel drugs by analysing their neighbouring communities once they were integrated in the network.
Missing data were integrated in the calculation.
Finally, this study indicates how in silico analyses should be integrated in early phases of biomarker development in order to avoid unnecessary laboratory work.
