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All analyses were derived using census counties.
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Data analyses and plots were derived using the R statistical package (R Development Core Team 2008).
For the purposes of analyses, BMI Z-scores were derived using the WHO reference (World Health Organization, 2009).
For tumor-based analyses, RRs (95% CI) were derived using generalised linear models with negative binomial distribution.
The comparative molecular field analyses (CoMFA) and comparative molecular similarity indices analyses (CoMSIA) based 3D-QSAR models were derived using pharmacophore-based alignment.
The relationships between (1) overnight urinary aMT6s/Cr and (2) total urinary overnight 8-oxodG and 8-oxoGua were derived using regression analyses, with age and BMI (or weight) as the covariates.
Survival curves were derived using Kaplan Meier analyses and comparisons performed using log-rank tests.
Models were derived using backwards selection.
The socioeconomic status used to analyse the data was derived using asset index.
19 The apparent Somer's D (Dapp) was derived using stepwise Cox proportional analyses.
Utilities used for the base case of the analyses were derived by using patients' rating scale values and transforming these into utilities with the "Torrance" function which is based on preferences elicited via the standard-gamble in a sample of Canadian citizens [ 16].
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CEO of Professional Science Editing for Scientists @ prosciediting.com