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Analyses were conducted using SAS version 9.3.
The analyses were conducted using LA-ICPMS.
Spatial analyses were conducted using GIS (ArcView).
Descriptive analyses were conducted using percentages, means, and standard deviations.
The analyses were conducted using SPSS version 20.0 (IBM, USA).
Sensitivity analyses were conducted using alternative efficacy and tolerability data.
All regression analyses were conducted using R software (www.r-project.org).org
The analyses were conducted using SPSS version 16.
All analyses were conducted using SPSS software (13.0).
Univariate and multivariate analyses were conducted using RStudio.
All statistical analyses were conducted using R version 3.1.3.
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