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In addition, Hardy Weinberg equilibrium (HWE) analyses were computed by Haploview 4.2 software, considering equilibrium when p > 0.05.

The significance threshold was set at a α value of 0.05, and all analyses were computed by an external statistical team (Onmedic) using the SAS System statistics software (Version 9.4 .. Of 84 patients starting the study, 42 were allocated to the treatment group and 42 to the control group (Fig. 1).

Statistical analyses were computed by χ goodness-of-fit tests and Fisher's exact probability.

All of these descriptive analyses were computed by method of administration.

All statistical analyses were computed by using Stata 8.0 (Stata Corporation, College Station, TX, USA) with a significance level of <0.05.

Latency analyses were computed by searching for the maximum differences in the PLV values between complex words and simple words and tested using the sample t-test.

The log-rank test in the Kaplan Meier analyses was computed by GraphPad Prism® version 5.0 (GraphPad Software, La Jolla, CA).

CFA models and invariance analyses were computed in accord with the procedures described by Byrne (2012).

All analyses were computed for the complete sample and later stratified by gender.

These analyses were computed with respect to two different onsets within the same trial, that were separated by a long and variable interval (mean duration = 4750 ms).

Analyses were computed using IBM SPSS Statistics (version 24).