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RCTs containing gender subgroup analyses were assessed for quality using assessment criteria adapted from Pincus et al 25 and Sun et al. 26 'Yes', 'No' or 'Unclear' were recorded as responses to the following quality appraisal questions: Was the subgroup hypothesis considered a priori?
Data resulting from in silico analyses were assessed for occurrence patterns in chosen taxa databases.
All statistical analyses were assessed for significance at the 95% CI.
Descriptive statistics for safety analyses were assessed for the ITT population.
Analyses were assessed for adherence to linear mixed effect model assumptions.
All statistical analyses were assessed for statistical significance at the p < 0.05 alpha level.
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Statistical analyses were assessed by SPSS for Windows software (version 12.0, SPSS Inc., Chicago, IL, USA).
Statistical analyses were assessed with SPSS for Windows v12.0.1 (SPSS Inc., Chicago, IL, USA) and SISA (http://home.clara.net/sisa/).clara.net/sisa/
Statistical analyses were assessed by one-way ANOVA for comparison among multiple groups and by two-tailed Student's t test for comparison between two groups.
Node support values in MP analyses were assessed using non-parametric bootstrapping for 1000 pseudo-replicates (10 random taxon addition sequence replicates per pseudo-replicate).
Values of time exposure for RT3DE analyses were assessed using a paired t-test and were expressed as mean ± SD.
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