For topics for which we could identify eight or more meta-analyses, we also evaluated whether the overlapping meta-analyses differed in their eligibility criteria regarding the breadth of interventions being assessed and the eligible settings.
This result might be somewhat conservative for exploratory analyses; hence we also evaluated the abundance changes for the 1129 proteins only quantified in the iTRAQ study.
For analyses restricted to those with HIV, we also evaluated the CD4+ T cell count and use of anti-retroviral therapy (ART) at baseline as potential confounders.
For analyses restricted to those with HIV, we also evaluated the CD4 count and use of ART at baseline as potential confounders.
With PCOORD, which can detect grouping of deep branches and has been used in analyses of virus sequence variation [ 56], we also evaluated resolution to the level of super-order.
We also evaluated these covariates, restricting analyses of interaction to only those subjects with information available for variables such as family history, with categorical variables divided into quintiles.
We also evaluated the references in relevant review articles and meta-analyses to identify other potentially eligible studies.
We also evaluated the effect of in utero exposure by simple linear regression analyses on the two outcomes of interest.
22 Where available, we also evaluated in more depth the quantitative results of the meta-analyses of observational associations and potential hints of bias in these meta-analyses.
