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From these analyses, the necessity of adjusting the differential prioritization based on the dataset of interest is established.
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The analyses reveal the necessity of detailed consideration of the most critical launcher components.
The results of the analyses show the necessity of additional studies prior to choosing the most promising blanket concept for further development.
At least for a subset of ERα-dependent carcinomas, our genomic analyses emphasize the necessity to consider the impact of additional extracellular signals on the effectiveness of tamoxifen as an antagonist.
The framework for analyses highlights the necessity for collaborations and partnerships.
A common theme in our analyses is the necessity of an increase in public and researchers' awareness of the detrimental effects of publication bias on health care.
The performed model analyses highlight the necessity, for a heterogeneous population, of quantifying the sensitivity on the population level, and not just of the nominal cell, even though this is much more convenient, computationally speaking.
One of the main limitations of kinetic analyses is the necessity to draw serial arterial or arterialized blood samples to obtain the blood input function required by the mathematical models [ 1].
Interestingly, while both substances revealed comparable cytotoxic effects on human ESCs in this study, only ATRA but not 13CRA were shown to be cytotoxic in mouse ESCs in previous analyses, indicating the necessity of developing hESC-based assays for the assessment of human-specific developmental toxicity.
If a proportion of the tumour sample is tetraploid (4n total chromosome complement), which often happens in a number of cancer types, this is not detectable by current SNP-aCGH analyses, due to the necessity to normalize DNA content between sample and reference.
The overlapping confidence intervals in our analyses point out the necessity of a study comprising a larger sample of hospitals.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com