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BV conducted the immunohistochemical analyses, scoring and interpretations.
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AVD conceived the design of the study, performed the statistical analyses, scored the mind maps, and drafted the manuscript.
In all subgroup analyses score values showed a quite similar range and differences did not turn out to be significant between the groups (Table 4).
Although assessment of study quality is considered important for systematic reviews and meta-analyses, scoring methods have been considered problematic [ 7] and may not accurately assess the quality measures of interest [ 8].
Prior to analyses, scores of the 18-item SRS were gender-weighted, such that the recommended cutoffs for screening in population-based settings were consistent with weighted scores of 1.078 for boys and 1.000 for girls.
In these analyses scores were dichotomized in order to generate the ORs.
For statistical analyses, scores of 0 300 were considered negative/low expression, and scores of 301 400 were considered positive/high expression.
For statistical analyses, scores 2 and 3 were grouped together: 1 = mild signs and 2 & 3 = moderate/severe signs.
In these analyses, scores from blast reciprocal hits are used to cluster proteins in Ensembl for all species.
Similar to the previous analyses, scores were scattered along the PC1 axis and its loadings had only positive values.
Based on previous analyses, scores of 0 to 3 are considered mild, 4 to 6 are considered moderate, and 7 to 10 are considered severe [ 24].
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