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HPLC-ESI-MS/MS analyses revealed a decrease in the intracellular GSH levels and an increase in the ophthalmic acid (OPH) levels during hGluc treatment.
In fact, GC MS analyses revealed a decrease in total cellular and mitochondrial PI, and mitochondrial PE quantities.
Assuming chloroform extraction does not lead to degradation of poly 3HB), GPC analyses revealed a decrease of the original molecular weight of poly 3HB) isolated through treatment with sodium hypochlorite by 50 – 70%.
Since analyses revealed a decrease of 61% (n = 33) in fluorescence intensity, a release of neurosecretory granules is suggested.
Biochemical analyses revealed a decrease in respiratory chain complex III activity in patient's skeletal muscle, and a combined enzyme defect of complexes III and IV in fibroblasts.
Meanwhile, histological and immunohistochemical analyses revealed a decrease in Ki-67-positive cells, MMP-9-positive cells and an increase in cleaved caspase-3-positive cells upon nifuroxazide.
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Furthermore, these analyses revealed a decreased expression of different members of the Wnt-pathway (e.g. Fzd2) and a strong upregulation of Myc (Fig. 3I).
N-Terminal acetylome analyses revealed a decreased acetylation of a subset of NatA and NatE substrates in Ogden syndrome cells, supporting the genetic findings and our hypothesis regarding reduced Nt-acetylation of a subset of NatA/NatE-type substrates as one etiology for Ogden syndrome.
These analyses revealed a significant decrease of both cell subsets in crt−/− FLC (Fig. 2).
Statistical analyses revealed a significant decrease of neuritic length (−25%) in ExpHtt expressing neurons when compared to Htt-transfected cells.
Quantitative analyses revealed a significant decrease (P = 0.0001) of 40% in the amount of LAMP-2 recruited to the SCV of ΔsseJ/ΔsifA mutants relative to ΔsseJ (Fig. 2b).
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