Sentence examples for analyses of the variant from inspiring English sources

However, analyses of the variant with SIFT, PolyPhen, and SNPs&GO showed that most likely the change is not pathogenic.

Analyses of the variant sequences that exist in human populations demonstrate that sites in stems of the predicted secondary structures are under stronger evolutionary constraint than sites on loops/bulges, which are still more constrained than non-conserved sequences.

We first performed single-locus analyses of the variants that surviving Hardy-Weinberg equilibrium test (n = 106).

The results of the functional analyses of the variants investigated in this study are summarised in Table 2.

At this stage, because we only have samples from the index individuals, no segregation analyses of the variants have been performed, but these families clearly warrant additional studies.

In contrast, the RFQ-RR analyses of the two variant proteins clearly reveal that they form distinct millisecond intermediates.

18 In turn, in single locus analyses of the CYP2C19*17 variant, about 20% of people classified as carriers of the *17 allele and about 35% of those classified as non-carriers were harbouring at least one *2 allele.

Collectively, single-gene and genome-wide analyses of the RNAPII variant identified at PRC-repressed chromatin demonstrate an unexpected molecular coassociation and synergy between the seemingly antagonistic Polycomb and RNAPII complexes.

Simple logistic regression analyses of the 1858T variant, HLA-SE and smoking after stratification for anti-CCP antibodies showed that smoking was a risk factor for RA in both the anti-CCPantibody seropositive group and the anti-CCP antibody-seronegative group (OR = 6.15, 95% CI = 4.68 8.07 and OR = 3.51, 95% CI = 2.46 5.01, respectively).

Significantly, the analyses of these variants revealed that NDR1-PIF, an NDR1 variant containing the PRK2 hydrophobic motif, remains hyperactive independent of hMOB1/NDR1-PIF complex formation.

Since genotype-phenotype analyses of the NOD2 variants p.Arg702Trp, p.Gly908Arg, and p.Leu1007fsX1008 have also provided strong evidence for the existence of a NOD2-related CD phenotype, these studies have not only changed our understanding of IBD pathogenesis but have also implications for clinical practice [21], [22], [23], [25].