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In contrast, H2BE appears to undergo higher levels of ubiquitination at Lys120, though analyses of the modification in H2be-KO and H2be-GF mice indicate that the association is correlative but not causative (not shown).
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These analyses allowed the modification of the geometrical parameters of the traditional screen and to design the new one.
Subgroup analyses of the possible effect modification of the association between increased serum PCT levels and death or a GOS of 1 3 by infections, different seizure types at SE onset, and acute etiology, may be hampered by the limited sample size.
In analyses of effect modification, the relationships between A1C and mortality or the combined outcomes were not significantly different for those with differing durations of diabetes (data not shown).
To analyse the effect of the modification for the HA binding behaviour, the hemagglutinin H5 was immobilised as ligand to the SPR sensor chip surface.
Likelihood ratio tests were applied to evaluate statistical significance of the interaction terms (nested within the main effects model) in the analyses of effect modification, that is, variation in incidence trends by country, age group and sex.
The first genome-wide, single-base resolution maps or 'methylomes' of methylated cytosines in a mammalian genome — from human embryonic stem cells and fetal fibroblasts — are now published, together with analyses of the transcriptome, histone modifications, and sites of DNA protein interaction for several regulatory factors.
Analyses of the post-translational modifications of proteins, small molecule signaling events, or cell physiological processes would certainly provide an increased understanding of the mechanisms of OP toxicity.
Time-course analyses of histone modification in the same cell cannot be performed using immunofluorescence because the preparation needs the fixation of cells4.
Deterministic sensitivity analyses showed that the modification of key parameters of the model had very little impact on the cost-effectiveness of posaconazole and, as such, the model is considered consistent in all the established assumptions.
The issue of uncertainty can be further managed through scenario analyses based on the modification of the underlying assumptions or data sources of the model.
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