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Signatures from these experiments were derived using the Bayesian Factor Regression Modeling (BFRM) software detailed in [19], and that has been used in multiple previous analyses of similar data [31], [38].
Based on previous statistical analyses of similar data, from collections within which each isolate's ExPEC status could be inferred based on ecologic source or experimental virulence, isolates were classified as ExPEC if positive for >2 of these 5 defining virulence markers (4 ).
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This is in contrast to a comparative study [22 24] which used the same type of analyses and similar data to predict C sequestration within several topographically unique units and the entire federal state of Baden-Württemberg.
This value is also confirmed by computational analyses of replication data similar to ours (de Moura et al. 2010; Yang et al. 2010).
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Similar analyses of GST data for this cohort reflect comparable trends (data not shown).
We expect that such methods can be generalized and of benefit for alternative analyses of genomic data or similar clustering of observed events over time.
Previous multivariable analyses of EDHS data showed similar results in Lower Egypt, increased stunting with age, among boys, and with longer birth intervals in children younger than five years of age [ 25].
Finally, similar analyses of the data elicited in other countries would be desirable to assess the extent of cultural variation on questionnaire performance which would facilitate the decisions on how the questionnaire might be used in multi-national clinical studies.
Similar analyses of the data from tasks ii, iii, and iv yield the same conclusion for 29/30 cases (not shown; the exception is the AM-3O-BA triplet in task ii).
Given that biologic therapies were only recently introduced to the Quebec formulary, our study was unable to make any definitive conclusions about the potential effect of these novel therapies and later need for surgery, but analyses of future data using similar methods should investigate this issue.
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