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In analyses of alteration of the ETV1 gene it was not possible to examine the relationship between survival and duplication of the ETV1 foci because duplications were only found in five of the 23 cases examined (one C15orf21 fusion, one chr14 co-localisation, and three with unknown partners).
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The identified regions were subsequently integrated with corresponding Affymetrix expression data, with separate analyses of alterations in Line2-T500, Line3-T200, and Line2-T500 and Line3-T200 combined.
Our in vitro mutagenesis (experimental) and population genomic (computational) analyses of alterations in the mutational behavior of [GT/CA]n repeats with increasing length are in remarkable agreement.
In the XRD analyses of the alteration products, no clear peaks of magnetite were identified owing to its small quantities (below the detection limit).
In Exp-350, the EPMA analyses of the alteration products revealed that calcite crystals had a relatively low FeOtotal content (0.1 0.8 wt.%) and that the serpentine and smectite/chlorite mixture had FeOtotal contents of 14 17 wt.% (Fig. 6e; Table 3).
The XRD analyses of the alteration products revealed that all the experiments generated a certain amount of serpentine during the hydrothermal reactions (Fig. 2), indicating that serpentinization occurred during these experiments.
Analyses of the alterations further suggest an epigenetic link.
However, comprehensive analyses of methylation alterations in SSA and MSI cancer have not been conducted.
Indeed, a major effect mutation typically disturbs hundreds or thousands of the genes, albeit to different degrees [ 34- 37], as revealed by whole genome analyses of transcriptome alterations.
As BM aspirations are less accepted by patients than taking blood samples, the analyses of genetic alterations in blood from tumor patients might become a particularly attractive approach to assess MRD.
This review focuses on the possible clinical value of array-based comprehensive analyses of molecular alterations, especially aberrant DNA methylation, in non-tumor liver tissue to clarify the risk of hepatocarcinogenesis. Carcinogenetic risk estimation based on specific methylation signatures may be advantageous for close follow-up of patients who are at high risk of HCC development.
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