Analyses were performed in the modified intent-to-treat population (defined as all patients randomised in the study who received at least one dose of TCZ and who had baseline and postbaseline synovitis, osteitis or bone erosion scores in the wrist or in 1 5 MCP joints) and were based on observed data with no imputation for missing data.
As sensitivity analyses, we examined improvement in the modified Disease Activity Score 28 (mDAS28), which is calculated without results of acute phase reactants as well as achievement of remission using the mDAS28 cut-off of <2.6 (eg, baseline mDAS follow-up mDAS follow-up
The status of p53-Lys acetylation was analysed in these modified cardiomyocytes using IP.
Further, the activation of 15 p53 target apoptotic genes was analysed in these modified cardiomyocytes and results showed that only H9c2 cells upon SD treatment activated the apoptotic genes (Fig 5F).
In model 2 multivariate analyses, the modified PVN classification also showed significant associations with tumour recurrence and tumour-related death.
In model 2 multivariate analyses, the modified PVN classification significantly increased the trend hazard ratios for tumour recurrence (P<0.001) and tumour-related death (P<0.001).
In model 1 multivariate analyses, the modified PVN classification was significantly associated with tumour recurrence (P<0.001) and tumour-related death (P<0.001).
In model 2 multivariate analyses, the modified PVN classification was significantly associated with tumour recurrence and tumour-related death, but the Nottingham Prognostic Index was not significantly associated with tumour recurrence or tumour-related death (Table 6).
Next, we analysed the localization of the modified sulphamidase enzymes in transfected cells.
ST-segment depression was rare in the modified aVF lead, and all subsequent analyses are based on findings in the modified V5 lead, the lead that most consistently identifies myocardial ischemia when it is present (Lanza et al. 1994).
XRD analyses confirm the formation of δ-TiN and tetragonal ɛ-Ti2N phases in the modified layer.
