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No other changes in hematological analyses in the CopDiff period (2000 2010) were performed.
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These higher results are also included in the CopDiff database.
In conclusion, we find this approach too cumbersome and not suited to answer apparent research questions in the CopDiff database.
Exposure for the cases is then determined by the latest measurement in the CopDiff database within a fixed period before the (first) occurrence of the outcome.
We hereby encourage our peers to contact us in order to collaborate on new projects or to test hypotheses in the CopDiff cohort.
The nature of the data in the CopDiff database – the way the data are obtained, the dynamics of the capture population, the sheer amount of data – requires careful considerations regarding the methods used to analyze relevant hypotheses.
Moreover, controls will feature in the data only when a measurement in the CopDiff database is within the fixed period before the corresponding case's occurrence of the outcome.
We opt for choosing randomly one single measurement in the CopDiff database for each individual in order not to have to control for people that enter the cohort multiple times at different points in time.
For this reason, the result, in principle, cannot be transferred to the Danish population in general, and 2) the large amount of data in the CopDiff database will cause any test of the proportional hazard assumption to reject this with high probability.
In time, the merging of the CopDiff database with other population-based registers such as the Danish Drug Prescription Register, the Danish Heart Register, the National Diabetes Register, and the Danish Psychiatric Central Research Register will allow for exploration of new areas of research.
The CBC requests from the period July 1, 2000 until January 25 , 2010were included in the first step of building the CopDiff database (Table 1).
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