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Ancillary analyses: in a substantial number of patients, patch tests became negative after the treatment and the NOC doses able to elicit symptoms at the end of the study changed from baseline.
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In contrast, in our analyses, although a substantial proportion of the estimates of individual genetic covariances were negative (11/28; Table S3), in general we found overall genetic constraints to be relatively mild and to result mainly from genetic variances rather than from genetic covariances among traits.
Like the effects of the craving induction, the influence of DRD4 VNTR genotype was mixed, exhibiting a negligible influence in the factorial analyses but a substantial influence in the continuous analyses.
Importantly, nearly all proteins identified in both the UVPD and optimized HCD analyses demonstrated a substantial increase in confidence in identification (as defined by an average decrease in E value of ∼40 orders of magnitude) due to the higher number of matched fragment ions.
We addressed limitations pertaining to this assumption in the sensitivity analyses, where a substantial (±50%) variation in the key input parameters was implemented to clearly identify the main drivers of the results.
In silico analyses indicate a substantial proportion of these mutations are potentially deleterious.
The treatment group by within-group analyses, showed a substantial significant decrease in level of depression, a significant increase in the knowledge about epilepsy as well as a significant decrease in all measures of neurotic disorders except for hysterical sub-scale.
In both analyses, a substantial number of genes were differentially expressed and this number varied according to the fold change value (FC).
We show by systematic and curated molecular phylogenetic analyses that a substantial fraction of genes in the lineage-specific core and shell gene sets was acquired from bacteria, implying directional and ongoing bacteria-to-archaea HGT.
The analyses reveal a substantial effect of formal learning in school over and above the effect of aging.
On the contrary, our analyses revealed a substantial negative association between openness and income.
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