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Data from additional one participant were discarded from all analyses due to registration failures.
One subject was not included in hypomania analyses due to unavailability of clinical data.
Data from three participants were excluded from fMRI analyses due to excessive head movement during scanning.
Bremer Bay was not included in these analyses due to the different survey methodology (see Methods).
We excluded two DYS385 loci from all current analyses due to technical issue.
Credibility intervals narrow considerably in combined analyses relative to separate analyses due to the increased amount of data.
Moreover, this device reduces the turnaround time of the analyses due to an automatic syringe change.
A major limitation of this study is a relatively small sample size for several analyses due to the integration of diverse methodologies and participant compliance.
However, the results scatter in the sensitivity analyses due to limited evidence of some key input parameters.
There were signs of moderate to high heterogeneity in these two analyses due to the inclusion of surgical ICU patients.
Molecules with more than 80 heavy atoms were excluded from the MCES analyses due to performance limits.
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