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Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses.
This low frequency is undoubtedly due to the fact that only a handful of the structural subunits and assembly factors of complex I are analysed in each study.
For meta-analysis, nine articles (including the six IMPACT articles) used only a two-step approach where the IPD was firstly analysed in each study separately, and then in the second step the summary data obtained (e.g. hazard ratios, odds ratios) were synthesised using a traditional model for meta-analysis of aggregate data [ 52, 53].
The selected studies were assessed and a record was made of the specific study characteristics including type of study, design, number of participants (n), type of proteomic technique used and the exact nature of the sample analysed in each study (whether serum, urine etc).
All the zones analysed in each study area are less than 40 km from the centre of Barcelona (Plaça de Catalunya) and 45 km from the centre of Madrid (Puerta del Sol).
The number of participants analysed in each study ranged from 85too 1 212.
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Two reviewers (M.B. and A.N). independently extracted statistical data on all risk factors considered for univariate or multivariate analyses in each study.
Unfortunately a detailed comparison of different assays is confounded by the virtual absence of common accessions and the adoption of different statistical analyses in each study [ 6].
JD, SJH, RR, and SS helped to perform the primary statistical analyses in each study and shared responsibility for the interpretation of results and critical revision of the manuscript.
In the placebo/PR groups, mean EQ-5D VAS did not return to values similar to baseline until Week 72 in either study.Sensitivity analyses in each study, including a LOCF approach, and comparison of patients with and without baseline FSS scores in the PILLAR study indicated that the EQ-5D VAS results were unaffected by missing data.
DIC helped to conceive and design the experiments, helped to perform the primary statistical analyses in each study, shared responsibility for the interpretation of results and critical revision of the manuscript, and contributed to a critical revision of the manuscript for important intellectual content.
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