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In addition, in order to control for potential differential shrinkage of layers 2 and 4 for individual cases we calculated the percentage of the cortical width that each case represented and analysed differences between groups at p<0.05.
We calculated median call times and analysed differences between groups using the Mann-Whitney U test with SPSS software.
We analysed differences between groups using mixed models in IBM® SPSS® Statistics18.0 to adjust for baseline characteristics and cluster effects.
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Categorical data were presented as numbers (percentages), and differences between groups were analysed using χ test.
Differences between groups were analysed according to the intention to treat principle.
The Mann–Whitney test was used to evaluate differences between groups of analysed MM patients and HV.
Statistical differences between groups were analysed and calculated by one-way analysis of variance (ANOVA) from at least three independent experiments.
1 Data are mean (S.D ., and differences between groups were analysed using independent samples t-tests. 2 Data are median (interquartile range), and differences between the groups were analysed using Mann Whitney U-tests.
Differences between groups in adhesion coverage were analysed using pairwise Wilcoxon tests with Bonferroni correction for multiple testing.
Continuous variables were expressed as medians with inter-quartile ranges and analysed with non-parametric statistics (Kruskal-Wallis, Mann–Whitney tests) for differences between groups.
Two measures of treatment effects on PFS/TTP and OS were analysed: (1) the absolute differences between the treatment groups in median PFS/TTP (in months) vs the absolute differences between groups in median OS (in months) and (2) the negative of the natural log of the HR for PFS/TTP (−ln HRPFS/TTP) vs the negative of the natural log of the HR for OS (−ln HROS).
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