In all analyses, this patient has remained in the TOT group to which she was allocated.
As in reality this patient was treated with anticoagulants based on the presumed diagnosis of pulmonary embolism, for the main analyses we analysed this patient as having pulmonary embolism, yielding the failure rates as presented in the figure and table 3.
Imaging analyses in this patient showed bilateral temporal atrophy on MRI as well as bilateral temporal hypometabolism on PET.
The general symptoms and results of the serologic tests and molecular analyses for this patient were consistent with a hantavirus infection.
In three patients, the specimens represented all five zones; in one patient, the specimens showed only a tumour without surrounding conjunctiva because of diffuse tumour growth (therefore only the tumour zone was analysed in this patient).
The reason why the significant association was observed only in the patient subgroup using exclusively METH compared to controls is not known; however, further analyses in this patient subgroup could reveal the reasons for their predilection for METH alone.
This study is one of the largest global, multicentre, gene-profiling studies to be conducted in NSCLC to date and shows the feasibility of carrying out prospective tissue-based analyses in this patient population.
In multivariate analyses within this patient group, Mammostrat® scores were independent predictors of RFS (P = 0.025 with nodal status, pathological size, multifocality, menopausal status and HER2), of DRFS (P = 0.005 with nodal status, pathological size, multifocality and HER2), and of OS (P = 0.0023, with pathological size, grade and nodal status also significant).
When serum PSA level, age, metastasis and Gleason grade at diagnosis were analysed for this patient, cohort using the Kaplan Meier log-rank method, PSA at diagnosis (P=0.036) and Gleason score at diagnosis (P=0.010) were associated with shorter time to biochemical relapse.
Previous analyses of this patient series estimating the hazard ratio for relapse at 6 12 month intervals reported peaks of relapse at 18 months and 60 months and then a tapered plateau like tail of relapse extending up to 15 years [ 2].
