Sentence examples for analogous substitution from inspiring English sources
Four of the synthesized compounds, possessing analogous substitution pattern, were found able to inhibit at low micromolar concentrations endothelial cell proliferation, migration and differentiation, constitutively or in response to Vascular Endothelial Growth Factor (VEGF) and to attenuate VEGF-induced phosphorylation of VEGF receptor-2 and downstream kinases AKT and ERK1/2.
Finally, the analogous substitution to T790M in BCR-ABL, T315I, is responsible for acquired resistance to ABL inhibitors in chronic myelogenous leukemia (CML) but has also been detected in CML patients before treatment [13].
Furthermore, when the analogous substitution is made in the yeast protein, yMLH1-G64E, this protein does not sustain MMR fully and is as compromised as yMLH1-G64R.
This result contrasts with a previous report in which it was demonstrated that the analogous substitution in amFP486 results in a protein that is not blue-shifted relative to avGFP-derived CFP [ 23].
The analogous substitution in the D-loop of the Smc1 ATPase active site, smc3-D1161E, nonlynly fails to act as a cohesion activator but also is unable to support viability, fails to load cohesin to DNA, and cannot generate cohesion.
An analogous substitution is made for particular observables that are used with the Reporter property: instead of displaying 'protein/peptide modification: abnormal' where the Reporter is carboxypeptidase Y, 'carboxypeptidase Y (Prc1p) modification: abnormal' is displayed, giving an immediate indication that the phenotype involves the vacuolar protein sorting pathway.
Our analysis of analogous substitutions in the homodimeric Rad50 protein shows similar reductions in the ATPase activity.
An analogous E17K substitution in AKT3 has also been found in melanomas (Davies et al, 2008).
In contrast, the analogous alanine substitution in RPEL1MAL, which contains an arginine at this position, reduced affinity only 3.5-fold (Kd=3.7±0.5 μM), whereas conversely, replacement of RPEL2MAL P126 with arginine (analogous to RPEL1MAL), also reduced binding affinity (Kd=19.5±3.1 μM).
To test more directly whether the two active sites played distinct roles in cohesin regulation, we compared the phenotypes of smc1-D1164E to smc3-D1161E, the analogous glutamate substitution of the D-loop aspartate of the Smc1 ATPase active site.
The analogous R150H substitution of the DRY motif in zebrafish sphingosine-1 phosphate receptor 2 (S1producesuces a mutation, miles apart m (milm93), that not only disrupts signaling but also impairs heart field migration.
