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A comparison between the observed folding mechanism and that of a peptide β-hairpin analog suggests that although native topology defines the character of the folding landscape, the statistical weighting of potential folding pathways is determined by the chemical nature of the polymer.
The concomitant loss of cytotoxicity and intercalation in the phenyl voreloxin analog, and the increased cytotoxicity of the more intercalative fused phenyl analog, suggests the requirement for intercalation for anticancer cell cytotoxicity of quinolone analogs.
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The improved blood brain barrier permeability and enhanced antinociceptive effect of the novel glycosylated analog suggest that it may be a promising template for design of potent analgesics.
The uptake of linear HER-GLP-1 appeared to be relatively faster compared to the branched HER-GLP-2 analog, suggesting that the position of the lipid moiety might affect the uptake of GLP constructs by DCs.
Interestingly, IL-1β was detected after exposure of LPS-pretreated BMDM to cytarabine, which is another nucleoside analog, suggesting that not all nucleoside analogs behave identically.
However, there was a relaxation to 8-bromo-cGMP 8-bromo-cGMP 8-bromo-cGMPlog, suggesting that the lacellf respermeant NO donors resides in the generation of cGMP, ranalogthan a defect in the resuggestingcGMP.
This is of particular relevance as a clinical study on a subcutaneously administered prostacyclin analog suggested that patients who tolerate a higher dose of these drugs achieve greater improvement in disease markers such as exercise capacity [ 23].
Morphological resemblance between fossils and recent analogs suggests that cyanobacteria are indeed a very old group of bacteria (see Golubic and Seong-Joo 1999) and that at least some morphological traits have been maintained over time (Golubic and Hofmann 1976; Golubic and Campbell 1979; Schopf 1992b).
The activity profile of forty four new α-pyranone carboxamide analogs suggests the role of an aromatic motif in the B region to add a synergistic effect to NHOH motif at 4-position and revels an anti-HCV activity determinants motif under this scaffold.
Analysis of the fibril inhibitory activity for our somewhat small set of aryl analogs suggests that TTR inhibition scales with the size of the ortho-substituent, with 11 (CF3) and 13 (OMe) having the largest groups at this position.
The difference between the ATP analogs suggests that the energetics differ which could shift (but not mitigate) the observed temperature dependence of closure depending on the analog used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com