Suggestions(1)
Exact(3)
The relationship between the GH-releasing potency and the analog structure is discussed.
Thus, strontium in zeolites is a good analog structure for inner-sphere complexation of strontium on silica gel, if it occurs.
The ligands in the analog structure were then transferred to the model, and the fitness of the ligand-model complex (BS-score) was calculated by comparing the local structure and sequence similarity in the binding site region.
Similar(57)
As already mentioned, ligand-based VS suffers from the bias caused by enrichments of analog structures.
While the parent taranabant bears highly potent binding affinity to cannabinoid CB1 receptor, neither of the analog structures improved CB1 receptor binding affinities.
This allowed the definition of a set containing 34 minimal acyclic riboside analog structures (Fig. 12).
This indicated that the N-terminal protective group may not play an important role in the activity and the analogs structure could be simplified to pentapeptide analogs while retaining good aphicidal activity.
Recently we reported that betaine-type metabolite analogs structure-dependently facilitate enzymatic hydrolysis reaction for α-glucosidases, β-glucosidases, and alkaliphosphatases.
We have identified and proposed some novel and potential lead molecules as reverse transcriptase inhibitors using analog and structure based studies.
A convex programming problem is solved, on-line, by reformulating the problem in terms of a piecewise smooth penalty function, and relying on a suitable analog variable structure system implementing the gradient procedure.
A variety of analog inhibitor structures were used by Xie et al. [ 1] to show that the minimal structure for binding at the substrate-binding site of P. stutzeri TyrA c is a six-membered ring with a 4-hydroxy substituent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com