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Two tests were employed for assessing analgesic activity, hot plate test for central analgesic activity and acetic acid induced writhing for peripheral analgesic activity.
was studied for finding its analgesic activity and anxiolytic potentiality.
They also showed moderate analgesic activity but no antioxidant one.
Most compounds showed significant peripheral and/or central analgesic activity.
The hot plate method is an established method for determining central analgesic activity [40].
Moreover, cetirizine was found to possess analgesic activity in mice (Priya et al. [2013]).
On the other hand, the ethyl acetate fraction showed no analgesic activity throughout the experiment time.
It is well established that various favonoids, alkaloids, steroids are involved in analgesic activity [32, 33].
Acetic acid induced writhing method was used to evaluate the analgesic activity.
Among the synthesized derivates, compounds 95, 96 and 97 (Figure 4) showed moderate analgesic activity.
These latter compounds exhibited comparable analgesic activity to the reference drug diflunisal, and superior analgesic activity compared to aspirin, in a 4% NaCl-induced abdominal constriction assay.
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