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We therefore tested whether isoflurane altered photodilation at an anaesthesia level under which responses to odour were conserved (0.7 1.1% isoflurane, arriving at the nose cone, see Methods).
Anaesthesia level was maintained via additional intraperitoneal boluses of pentobarbital (25 mg/kg/h).
To keep adequate anaesthesia level, continuous arterial blood pressure, heart rate, and end-tidal carbon dioxide were monitored during the surgical procedure.
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Nine rats were mapped at light anaesthetic depth including one rat mapped at both the deep and light anaesthesia levels.
Anaesthesia levels were assessed from the electrocorticogram (ECoG) and by testing reflexes to a cutaneous pinch of the hind paw.
Nine rats were mapped at light anaesthetic depth and six rats were mapped at deep anaesthesia levels, including one rat that was mapped under both light and deep anaesthesia.
ICP recordings for statistical calculations were collected for a 20-min-long period, starting after the animals were fully awake and the ICP values were stable and back to pre-anaesthesia levels.
Three of these explicative variables are numerical (age, surgical time and discharge time), and the other five are considered as categorical: gender (with 2 levels), ASA status (with 3 levels), surgical specialty (6 levels), ambulatory surgical incapacity (3 levels) and type of anaesthesia (3 levels).
Some advise cessation of LDA treatment 1 week before a planned delivery with epidural anaesthesia (evidence level IV).
Other experts do not stop LDA in pregnant patients with antiphospholipid syndrome, regarding the benefit of LDA as being greater than the small risk of haematoma connected with epidural anaesthesia (evidence level II).
This study also supports our previous assumption that if ScvO2 is used during general anaesthesia, higher levels should be considered as a target value than in the critical care setting.
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