However, there is still a big unresolved question regarding the lack of a coordinated metropolitan area planning issue.
Because cytoplasmic TDP-43 aggregates accompanied by a loss of nuclear TDP-43 have been found in ALS patients, a major unresolved question regarding TDP-43-mediated neurodegeneration is that whether the toxicity is triggered by a toxic gain-of-function or by a loss-of-function.
Another unresolved question regarding cellulose biosynthesis is whether cellulose fibril orientation, length or crystallinity may provide differential biomechanical properties to certain cell and tissue types and how this may correspond to a specific ecological niche?
An additional unresolved question regards the role of statins with regards to peripheral neuropathy.
After more than half a century of research, the dynamics of salt tectonics in the North Sea remains a contentious issue with unresolved questions regarding triggering and driving mechanisms.
A randomized controlled trial would be ideal to answer these and other unresolved questions regarding thoracoscopic lobectomy.
Statins, which lower serum cholesterol levels by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, have been used to treat PD, but there are many unresolved questions regarding their benefits (see review in Becker and Meier).
Unresolved questions regarding the design of clinical trials in this area were discussed at an international meeting in Florence, Italy in April 2012.
The motivation for our study was to address key unresolved questions regarding the neural circuit dynamics in PMd underlying somatomotor decisions.
Such analyses would undoubtedly advance our efforts to address the unresolved questions regarding the role of Royalactin in phenotypic polymorphism of female honey bees.
