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The reason is that due to highly underdetermined nature of our problem, subsampling of the input data sample could possibly lead to an unreliable inference methodology.
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Methods such as propensity score matching have been shown to avoid unreliable inference in parametric models.
Failure to consider the difference between the two types of trials may result in unreliable inference because the confidence interval for the true combined effect will be incorrect.
However, it should be recognized that the trees based on concatenated sequences, due to the possibility of their lumping together gene sequences with discordant evolutionary histories, can sometime result in unreliable inferences [ 32- 34].
"I am an unreliable narrator.
It's an unreliable narrator.
Is Brandon an unreliable narrator?
But an unreliable letter writer?
She is an unreliable narrator.
Is Ursula an unreliable narrator?
Was she an unreliable memory?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com