Two potent analogues possessing two different unprecedented modifications to the vindoline subunit core architecture were discovered that matched the potency of the comparison natural products.
We show that streptide bears an unprecedented post-translational modification involving a covalent linkage between two unactivated carbons within the side chains of lysine and tryptophan.
The third one is 'proteomics' in which protein and protein modification profiles offer an unprecedented understanding of regulatory networks.
Such data would represent an unprecedented resource to address important questions like when should treatment modification criteria be changed based on characteristics of the patient population.
Among other unusual features, this aromatic polyketide synthase (PKS) system encodes an unprecedented number of functionally diverse oxidoreductases, which are involved in the oxidative modification of a polyaromatic tridecaketide precursor by cleavage of three carbon-carbon bonds.
We have exploited the ability to explain distal tissue modifications in the dab fish (Limanda limanda) which has an unprecedented high occurrence of hepatic adenoma (up to 20%) when analysed from the natural environment.
With an unprecedented level of resolution, a detailed atlas of chromosomal structures (histone displacement, variants, modifications, chromosome territories, and DNA looping) and mechanisms underlying their establishment, provides invaluable insight into physiological as well as pathological phenomena.
In the past decade, a remarkable progress has been made in controlled NCA polymerization, which offers an unprecedented access to precision polypeptide and hybrid materials by combining with living radical polymerization, click chemistry, and/or post-polymerization modification.
An unprecedented arrangement, Downing Street said, to prepare for an unprecedented challenge.
It also presents an unprecedented opportunity to fully understand the fundamental functions and diversity of FAD2 proteins and their differing fatty acid modifications within a single plant species.
