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In addition, an unimputed data mining data set was constructed.
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In unimputed data, 90% of Irish children had a father of a manual social class background, compared with 82% of non-Irish children, at age 7.
For this reason, exposure is reported as a percentage bAnalyses with never use of antidepressants as reference, using unimputed data cAnalyses with never use of antidepressants as reference, using imputed data dAnalyses with past use of antidepressants as reference, using imputed data.
To reduce the initial number of variables, an univariable analysis (α > 0.157) was performed in both the imputed and unimputed data sets, thus all analyses were preceded by this pre-selection.
All plots were based on unimputed data.
We analysed rare binary outcomes by doing Fisher's exact tests on the original (unimputed) data.
Supplementary data are available detailing univariate predictors of VTEs and HRs for unimputed data (online supplementary tables 3 5).
No cases were dropped from the unimputed data sets and no imputation of missing values was performed on it.
And as the results for the imputed data were similar to those based on unimputed data, we only show the former in the paper.
We estimated coverage of the exon regions for seven populations by unimputed data and coverage for the CEU samples by imputed data.
We used Fisher's exact tests and Wilcoxon tests based on the original unimputed data to assess binary and continuous confounders respectively.
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