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It appears that most of the structures with decreased conformer model accuracy at RMSD cluster = 1.6 Å are simply due to an unfortunate culmination of pronounced partition-based clustering edge-effects for a set of flexible di- and tri-phosphate containing structures.
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"Game On" wasn't just a one-off episode that didn't work; it came across as the unfortunate culmination of a series of bewildering decisions.
In a formal statement on the cancellation, Mr. Mehta said he was "frankly shocked" by the Georgian government's actions and regretted "the unfortunate culmination of this honorable pursuit".
It is an unfortunate choice.
This is an unfortunate development.
Therein lies an unfortunate dynamic.
This is an unfortunate situation.
"It was an unfortunate coincidence".
That's an unfortunate result.
This was an unfortunate hiatus.
There's an unfortunate childhood.
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