Co-expression of KLK10 and KLK6 plays an unfavourable role in PDAC.
In the present study, using a case material containing ovarian carcinoma specimens, we found an association between MRP1 and grading and we observed that MRP4 displayed an unfavourable role in disease outcome.
These results suggest that in epithelial ovarian cancer, MRP1 may be a marker for aggressiveness because its expression was associated with tumor grade and support that MRP4 may play an unfavourable role in disease outcome.
The impairment of QoL in MS was strongly associated with increasing fatigue and depression, whereas clinical disability had a minor unfavourable role.
In renal cell carcinomas (RCC), while the expression levels of survivin and survivin-ΔEx3 did not show a decrease in late tumour stages in comparison with the early and intermediate tumour stages in 57 clinical RCC samples, survivin-2B expression was significantly decreased in late tumour stages (Mahotka et al, 2002a), indicating a possible unfavourable role of survivin-2B in cancer development.
Some of these biomarker studies described an unfavourable prognostic role of COX-2 in early breast cancer [ 8– 11].
Since less differentiated tumors are expected to be endowed with the greatest proliferation potential, thereby being chemoresponsive, the unfavourable role of MRP1 may be difficult to assess.
The unfavourable role of meat on cancers of the upper aerodigestive tract may be attributed to its content of animal fat and cholesterol, which were positively associated with OCP cancer in our study.
Our findings provide potent evidence of the unfavourable role of meat intake in the development of endometrial cancer, even at a low average level of consumption, and thus strongly support public health messages suggesting that women should be encouraged to lower their meat intake.
The unfavourable role of meat on cancers of the UADT has been attributed to its fatty-acid composition and the presence of nitrites, N-nitroso compounds, heterocyclic amines, and polycyclic aromatic hydrocarbons (Phillips, 1999; Zheng and Lee, 2009), although the issue remains unsettled.
The unfavourable role of high TOPO-II α expression was maintained only in the subgroup of platinum resistant recurrent ovarian cancer patients, be TOPO-II α expression evaluated as continuous variable (χ=5.1, P-value=0.024), or by means of the defined cutoff point.
