CPGC can provide the directional causality information without making any a priori assumptions about the underlying connectivity architecture or limitations about the number of regions.
We are aware that we are searching for a static configuration of the network, whereas the underlying connectivity in complex systems, including PPIs and gene-regulatory networks, is dynamic as it may change over time and under different conditions.
For example, contrast maps specific to a task have been shown to be sensitive to underlying connectivity networks, indeed, applying independent component analysis (ICA) to contrast maps from a task-based study reveals networks of regions showing common across-subject covariation, which resemble with widely studied resting fMRI networks [ 33].
This is likely due to a 'fortuitous' biasing of the task-based activity by the underlying connectivity.
Each SADS represents the spectrum of a particular microscopic subpopulation within the postulates of the model and its underlying connectivity scheme.
In this study, we sought to apply the NCA approach to analyze a network comprising TFs important for floral development and their targets using underlying connectivity information available in the AGRIS database.
Spatiotemporal patterns of activity appear to be shaped by the underlying connectivity architecture and strong inhibition.
We assess the accuracy of parcellations from four different aspects: (1) reproducibility across different acquisitions and groups, (2) fidelity to the underlying connectivity data, (3) agreement with fMRI task activation, myelin maps, and cytoarchitectural areas, and (4) network analysis.
Next, using targeted attacks versus random node removal, we demonstrated the potential utility of the proposed framework, as this intrinsic geometry is sensitive to alterations in the underlying connectivity.
Jimbo found that stimulating just one of the 60 electrodes with the tetanic pulse train resulted in complex changes in the strength of the underlying connectivity in which both enhancement and depression of synaptic strength were observed.
