Although the pathophysiology behind this is unclear, hypotheses include myocarditis and autonomic neuropathies [8].
While the cause of muscle cell death in DGC-related muscular dystrophies is unclear, a leading hypothesis is that damage to the sarcolemma during muscle contraction causes a loss of calcium homeostasis, leading to activation of proteases and eventual cell death [33].
Although the cause of impaired laryngopharyngeal sensitivity remains unclear, a few hypothesis have been risen: the use of inhaled coriticosteroids and anticholinergics may have an effect on the sensory mucosa of the laryngopharynx; laryngeal edema caused by smoking and presence of chronic cough, commonly reported in COPD patients, may contribute to reduced sensation [ 21].
Because the mechanism of migraine attacks is still unclear, the hypothesis of increased intracranial pressure as a provoking factor for migraine attack and cortical spreading depression seemed to be attractive.
While the pathogenesis of adynamic bone disease is unclear, one hypothesis that has been put forth is that Epo administration is associated with increased indexes of bone matrix formation [31].
First, it is unclear what hypothesis is being tested in either of the two papers.
The etiology of urethral duplication is unclear, no hypothesis explains the basis for all cases.
Although the mechanisms behind O3-induced cardiac changes remain unclear, onev hypothesis proposes that O3 leads to increased oxidative stress, resulting in lung inflammatory and permeability changes in addition to airway hyperreactivity (Tankersley and Kleeberger 1994; Zhang et al. 1995).
Although the functional significance of the Pe has remained rather unclear, three hypotheses about the Pe have emerged: The affective-processing hypothesis [45], [47] suggests that the Pe reflects affective processing of the committed error or its consequences.
Although the exact pathogenic steps leading from venous hypertension to venous ulceration remain unclear, several hypotheses have been developed to explain the development of venous ulceration.
While the exact mechanism between alcohol/substance use and perpetration of child neglect/abuse/VAW is unclear, several hypotheses have been suggested (Walsh et al. 2003; Kunitz et al. 1998).
