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Voxel-wise anatomical shape variation measures were computed by estimating the initial diffeomorphic mapping momenta from an unbiased control template.
However, a major strength of our study was selection of controls from the general population, providing an unbiased control group.
First, a randomly sampled subcohort of 709 children provided 542 nonwheezers as an unbiased control sample for analyses using this phenotype, as well as 167 wheezers.
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"Increasingly, social welfare scholars are relying on such statistical strategies as 'propensity score matching,' which permits us to construct a statistically unbiased control group, when we can't feasibly carry out a randomized clinical trial in the real world.
To overcome this statistical problem it is essential to use unbiased control groups.
The use of animal models has the prospect of minimizing some of the profound genetic and environmental variability often encountered in human proteome studies where unbiased control samples are often difficult to obtain [16].
The goal of unbiased control was achieved by recruiting both cases and controls at the same time and under same conditions.
Based on these reasons, we believe in this setting the use of test-negative controls will provide the most resource efficient and epidemiologically unbiased control group, and should be the only control group for the real case-control study.
One could also question whether patients who receive an injection of an anesthetic should be regarded as unbiased controls, since local anesthetic can have effects for a period exceeding the pharmacological activity of the drug.
Each manufacturer would be required to sponsor unbiased, controlled research of its opioid products, probably at universities, he said.
By using this "leave-one-out" estimation of expected control performance one obtains an unbiased estimate of the variance in control residuals, i.e. a leave-one-out cross-validation estimate [85].
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