The ultimate confirmation of a pathophysiological mechanism may be to design a therapeutic approach.
For example, the Michigan Neuropathy Screening Instrument (MNSI), used in the study of the aldose reductase inhibitor zenarestat, terminated for reasons of toxicity [ 2], represents the screening component of a two-step test requiring ultimate confirmation of neuropathy by measurement with the Michigan Diabetic Neuropathy Score (MDNS) [ 3].
"Are you Professor Manasse?" the filmmaker said, and the man answered yes in a German accent that was the ultimate confirmation.
""His ultimate confirmation will depend on that session".
This ultimate confirmation of Einstein's theory would be the end of one set of questions, but it would open up a whole new set of puzzles.
While revealing nothing new about his art, they offer assurance that the product is still reliable, especially if one takes quantity as ultimate confirmation of quality (Smith).
But Larry Bird could play basketball, and yesterday he received the ultimate confirmation of that when he was elected to the Nai smith Memorial Basketball Hall of Fame.
The show is the ultimate confirmation that, despite attempts to be as unpalatable as possible, punk was absorbed by the culture around it, not least by blue-chip fashion designers on the prowl for new ideas.
Perhaps the ultimate confirmation that Dr. Rieder, the white Jew, got black Christianity right came last month from the Rev. James A. Forbes Jr., one of the leading black ministers of Dr. King's generation.
For me, it is the ultimate confirmation of something I have been regaling friends with for 20 years and now, for the advancement of social science, feel compelled to publish.
