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With a LLD of 415 keV and an ULD of 680 keV, a sensitivity of 6.5% for the measurement geometry described in the 'Measurement geometry' section was measured.
The maximum of the NECR was found for an ULD of 550 keV and a LLD of 390 keV for the rat phantom configuration.
With a LLD of 415 keV and an ULD of 680 keV, a natural background of about 1,400 counts per second for each detector was measured.
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A total of 4,166 patients with a diagnosis of gout who were initiated on a ULD during the study period.
*Over the 12 months prior to initiation of a ULD; †over the 12 months after initiation of a ULD.
The NECR was decreased with the use of a higher LLD (400 keV instead of 250 keV) for the mouse phantom with a ULD fixed at 590 keV.
Our analysis focused on new users of therapy, which was defined as no dispensing of a ULD in the prior 6 months.
Simultaneous BPCTs were acquired in 8 patients on a dual-source-CT by applying LD (80 kV,200 mms,14×1.2 mm) on tube A and ULD (80 kV,30 mms,14×1.2 mm) on tube B. Image data from both tubes was reconstructed with identical parameters and post-processed using the HYPR-LR.
BPCT was performed with 80 kV tube voltage for tube A and B with a standard of reference LD protocol [12], [13] on tube A and ULD protocol on tube B. The LD and the ULD BPCT datasets were acquired simultaneously in one scan using tube currents of 200 mA on tube A and 30 mA on tube B. Automatic tube current modulation (CARE Dose 4D) was turned off during the acquisition.
The structures reveal a compact dimer made up of trimodular subunits containing an N-terminal kinase domain (KD), a ubiquitin-like domain (ULD), and an α-helical scaffold dimerization domain (SDD).
Recent X-ray crystal structure analyses have revealed that IKK2 contains three distinct domains: an N-terminal kinase domain (KD) followed by a ubiquitin-like domain (ULD) and a C-terminal scaffold dimerization domain (SDD).
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