The phrase "an substantial effort" is not correct in written English.
It should be "a substantial effort" because "substantial" begins with a consonant sound.
Example: "The team put in a substantial effort to complete the project on time."
Alternatives: "a significant effort" or "a considerable effort."
Fifteen artists were then asked to develop maquettes -- a process requiring a substantial effort with no guarantee of selection.
It is a substantial effort for a single performance.
We note that every program has its own set of parameters and fitting the best parameter combination for a particular dataset is a substantial effort.
Another disadvantage of this approach is that it relies on a set of single-phenotype statistical tests and combines the results afterwards in order to determine whether a marker is significantly affecting a subgroup of phenotypes, thus requiring a substantial effort in conducting appropriate multiple hypothesis testing.
I further agree with the author that the needs of these children must be met by a well planned strategy requiring a substantial effort by many people.
A growing number of bioinformatics resources are utilizing both the GO and ChEBI as part of a substantial effort to integrate a large set of biological ontologies for community use [ 21- 26].
The Guild harshly criticized The Times for not only exceeding its target of 100 job cuts, but also for hiring a number of new workers without making a substantial effort to retrain veteran employees.
Since the introduction of PHN as a model for auto-immune glomerulonephritis [45], a substantial effort was made to identify responsible antigens.
Because of these problems, there is now a substantial effort to develop drugs with a spectrum of oestrogenic and anti-oestrogenic activity (the Selective Estrogenic Receptor Modulators or SERMS), which give a better profile of activity than oestrogen for women's health benefits.
In this sense, the implementation of a PRS tool within a broader system-level reform strategy would require a substantial effort in planning and communication with frontline clinicians, aimed at avoiding a feeling of change-saturation.
