Ectopic expression of Aurora-A sensitized the normally HR-competent PIR12 cell line to the potent PARP inhibitor KU0058948 (Farmer et al, 2005; Fig 6D, E).
The antitumor agent Mithramycin A (Mit A) sensitizes various cancer cell lines to TRAIL-mediated apoptosis by downregulation of XIAP.
These studies predict that inhibition of filamin-A sensitizes cancer cells to specific therapeutic DNA damage agents.
In addition, while WT mice developed a sensitized response by day 3 (Fig. 2A, day 3, ##p<0.01 versus day 1), GASP-1 KO mice did not develop sensitization until day 4 (Fig. 2A, day 4, ##p<0.01 versus day 1).
In this study, we have examined the application of Mn or Co doped CdS nanocrystals as a sensitizing layer over titania nanotubular arrays synthesized via electrochemical anodization in photoelectrochemical applications.
Chronic beryllium disease (CBD) begins as a sensitizing cell-mediated immune response to beryllium antigen that progresses to granulomatous lung disease.
Cancer cells depleted of aurora-A were sensitized to the effect of chemotherapeutic agents, including taxanes, cisplatin, docetaxel and ionizing radiation.
For example, although inhibition of filamin-A sensitizes cells to radiation, cisplatin, and bleomycin, it surprisingly also confers a resistance to topo-isomerse poisons [ 126].
As in the colony formation assay, Aurora-A overexpression sensitizes MCF10A cells to irradiation in a dose-dependent manner.
It appears that consistent stress to the mother can cause an overly sensitized baby who has a lower stress threshold after birth.
Here we show that the MCL-1-specific inhibitor A-1210477 sensitizes these cell lines to navitoclax.
